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Interleukin-10 released by CD4(+)CD25(+) natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice

The 0.05 mg/kg/day dose met the primary endpoint (p=0.007) while the higher 0.10 mg/kg/day dose did not (p=0.16) the basis for the approved dose

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GHK-Cu enhances collagen synthesis (types I and III), upregulates glycosaminoglycan (GAG) production, and modulates the balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs)-thereby both promoting extracellular matrix (ECM) formation and controlling ECM degradation