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July 2003

, & George, T

ZUSAMMENFASSUNG DER ERFINDUNG (OFFENBARUNG DER ERFINDUNG)SUMMARY OF THE INVENTION (DISCLOSURE OF THE INVENTION) Die Erfindung betrifft ein Peptid, das eine freie Sure oder ein pharmazeutisch vertrgliches Salz davon und Ac-Nle-cyclo(-Asp-His-D-Phe-Arg-Trp-Lys)-OH ist.The The invention relates to a peptide which is a free acid or a pharmaceutical compatible Salt thereof and Ac-Nle-cyclo (-Asp-His-D-Phe-Arg-Trp-Lys) -OH

Excitatory neurotransmitters like glutamate facilitate synaptic transmission within the dorsal horn and dorsal root ganglia (DRG), amplifying pain transmission through ascending pathways conveying nociceptive signals from the periphery to the brain (Latremoliere and Woolf 2009