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Therefore, systematic evaluation of vitamin B12 status should be considered an essential component of the diagnostic workup for diabetic peripheral neuropathy, particularly in patients with concurrent metformin or PPI therapy, to ensure accurate diagnosis and optimize therapeutic interventions

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DSIP and Metabolism Studies on rat models have highlighted that Delta Sleep-Inducing Peptide may help change stress-related metabolic fluctuations, [13] which may induce mitochondria to switch from oxygen-dependent to oxygen-independent respiration

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