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The lean mass loss seen with these drugs largely mirrors what occurs with an equivalent hypocaloric diet and is driven mainly by a steep caloric deficit, lack of resistance training, and inadequate protein intake, not a unique catabolic effect of the medication

Although the study did not distinguish the efficacy among different heterozygous LMP variants, it confirmed that heterozygous mutations in the LMP pathway (including MC4R ) are associated with compromised long-term surgical outcomes, consistent with the findings in heterozygous MC4R P/LP variant carriers